The US-Singapore Free Trade Agreement (USSFTA) was signed by Prime Minister Goh Chok Tong and President George W. Bush on 6 May 2003 in Washington DC. The USSFTA entered into force on 1 January 2004 after it was approved by the House of Representatives on 25 July 2003 and by the Senate on 1 August 2003.

The agreement has helped Singapore exporters to benefit from tariff concessions, increase competitiveness and attract investors.

The USSFTA outlines the duties and obligations of Singapore and the United States (US) with regard to areas such as trade in goods and services, customs procedures, movement of business persons, intellectual property protection and the environment. It also sets out the guidelines for dispute settlement procedures.